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Open Access Highly Accessed Open Badges Review

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

Shruti R Saptarshi1, Albert Duschl2 and Andreas L Lopata1*

Author Affiliations

1 Centre for Biodiscovery and Molecular Development of Therapeutics, School of Pharmacy and Molecular Science, James Cook University, Townsville, Queensland, Australia

2 Department of Molecular Biology, University of Salzburg, Salzburg, Austria

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Journal of Nanobiotechnology 2013, 11:26  doi:10.1186/1477-3155-11-26

Published: 19 July 2013


Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.

Nanoparticle; Protein corona; Protein unfolding; Nanoparticle uptake; Circular dichroism