Review

Microfluidics in biotechnology

Richard Barry¹ and Dimitri Ivanov²

¹  School of Biological Sciences Royal Holloway, University of London Egham, Surrey TW20 0EX United Kingdom

²  "Laboratoire de Physique des Polymères, CP223 Université Libre de Bruxelles" B-1050 Brussels Belgium

author email corresponding author email

Journal of Nanobiotechnology 2004, 2:2doi:10.1186/1477-3155-2-2

Published:	31 March 2004

Abstract

Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. Microfluidics has been applied to DNA analysis methods and shown to accelerate DNA microarray assay hybridisation times. The linking of microfluidics to protein analysis techologies, e.g. mass spectrometry, enables picomole amounts of peptide to be analysed within a controlled micro-environment. The flexibility of microfluidics will facilitate its exploitation in assay development across multiple biotechnological disciplines.