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Open Access Research

Internalization of ferromagnetic nanowires by different living cells

Adriele Prina-Mello*, Zhu Diao and John Michael David Coey

Author Affiliations

Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and School of Physics. Trinity College Dublin, Dublin 2, Ireland

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Journal of Nanobiotechnology 2006, 4:9  doi:10.1186/1477-3155-4-9

Published: 5 September 2006

Abstract

The ability of living cells, either adherent or suspended, to internalize nickel nanowires is demonstrated for MC3T3-E1, UMR106-tumour and Marrow-Stromal cells. Nanowires were produced by electrodeposition, 20 μm long and 200 nm in diameter. Cell separation and manipulation was achieved for the three cell types. Applied magnetic field successfully oriented the internalized nanowires but no clear anisotropy is induced on the adherent cells. Nanowires tend to bind to cytoplasm metalloproteins and trigger lysosome reorganization around the nucleus. This work demonstrates the applications of nanowires in adherent and suspended cells for cell separation and manipulation, and further explore into their role in nanobiotechnology.