Nanocurcumin inhibits the clonogenic potential of pancreatic cancer cell lines. Colony assays in soft agar were performed comparing the effects of free and nanocurcumin in inhibiting the clonogenicity of the pancreatic cancer cell line, MiaPaca. Representative plates are illustrated for untreated cells (UT), void polymeric nanoparticle-treated cells (VP), free curcumin-treated cells (FC) and nanocurcumin-treated cells (NC), the last two at the equivalent of 10 μM curcumin dosage. All assays were performed in triplicates, and the mean ± standard deviations are presented.
Bisht et al. Journal of Nanobiotechnology 2007 5:3 doi:10.1186/1477-3155-5-3