Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates

doi:10.1186/1477-3155-6-12

Journal of Nanobiotechnology

Volume 6

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Gao ZG
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Shainberg A
Jacobson KA

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Enhanced A₃adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates

Athena M Klutz¹ , Zhan-Guo Gao¹ , John Lloyd² , Asher Shainberg³ and Kenneth A Jacobson¹

¹Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA

²Mass Spectrometry Facility, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA

³Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel

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Journal of Nanobiotechnology 2008, 6:12doi:10.1186/1477-3155-6-12


Published:	23 October 2008

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Supplementary figures 1–4. Figure S1: ESI (+) MS of G3 and G2.5 Dendrimers. Figure S2: ESI (+) MS of Compounds 12 and 13. Figure S3: ESI (+) MS of Compounds 16 and 17. Figure S4: Light and Fluorescent Microscopy of CHO or CHO A₃cells with Compound 15. The cells were plated 24 h prior to the experiment. The cells were incubated for 1 h with the 10 μM of 15 and imaged with light and fluorescent microscopy. A. CHO A₃cells, fluorescent image B. CHO A₃cells, light image C. CHO cells, fluorescent image D. CHO cells, light image.

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