Figure 2.

Amphotericin B solubilized in cationic bilayer fragments adsorbs a layer of carboxymethyl cellulose. Effect of CMC concentration on zeta-average diameter (A, C) and zeta-potential (B, D) of unloaded DODAB BF (A, B) or DODAB BF/AmB (C, D) at low drug-to-lipid molar proportion. Final DODAB and/or AmB concentrations are 1 and 0.005 mM, respectively. The three different moieties of the curves were named I, II and III corresponding to positive, zero and negative zeta-potentials, respectively.