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Sizing and zeta-potential of drug, cationic lipid and anionic polyelectrolyte in separate or as assemblies |
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| Dispersion |
[DODAB] (mM) |
[AmB] (mM) |
[CMC] (mg/mL) |
D ± δ (nm) |
ζ ± δ (mV) |
|
|
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| AmB in water |
--- |
0.005 |
--- |
433 ± 5 |
-26 ± 3 |
| DODAB BF |
1 |
- - - |
--- |
79 ± 2 |
41 ± 2 |
| DODAB BF/AmB |
1 |
0.005 |
--- |
79 ± 1 |
42 ± 2 |
| DODAB BF/AnB/CMC |
1 |
0.005 |
0.01 |
88 ± 1 |
40 ± 1 |
| 1 |
0.005 |
0.1 |
145 ± 1 |
32 ± 2 |
|
| 1 |
0.005 |
1 |
90 ± 2 |
-50 ± 2 |
|
| AmB in water |
--- |
0.050 |
--- |
360 ± 4 |
-26 ± 3 |
| AmB in IGP |
--- |
0.050 |
--- |
75 ± 2 |
-27 ± 1 |
| DODAB BF in IGP |
0.1 |
- - - |
--- |
75 ± 1 |
40 ± 1 |
| AmB/DODAB BF |
0.1 |
0.050 |
--- |
195 ± 3 |
9 ± 1 |
| AmB/DODAB BF/CMC |
0.1 |
0.050 |
0.001 |
199 ± 1 |
16 ± 1 |
| 0.1 |
0.050 |
0.01 |
1280 ± 80 |
4 ± 1 |
|
| 0.1 |
0.050 |
0.1 |
230 ± 2 |
-34 ± 1 |
|
|
Zeta-average diameter (D) and zeta-potentials (ζ) for different dispersions aiming at formulation of AmB in cationic lipid DODAB and CMC. Dispersions were prepared either in Milli-Q water or in IGP buffer. | |||||
Vieira and Carmona-Ribeiro Journal of Nanobiotechnology 2008 6:6 doi:10.1186/1477-3155-6-6 |
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