|
Pharmacokinetic parameters (Mean ± SD, n = 6) of CXB from C2, NGC2 and capsule |
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| Formulation |
tmaxa ± SD (h) |
Cmaxb ± SD (ng/ml) |
AUC0→tc ± SD (ng/ml.h) |
AUC0→αd ± SD (ng/ml.h) |
|
|
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| C2 |
12 ± 1.8 |
680 ± 100 |
14435 ± 1741 |
19711.3 ± 2012 |
| NGC2 |
12 ± 2.0 |
610 ± 148 |
13005 ± 1502 |
17507.3 ± 1654 |
| Capsule |
3 ± 0.8 |
690 ± 180 |
4366 ± 1015 |
4688.5 ± 1293 |
|
a time of peak concentration; b peak of maximum concentration; c area under the concentration time profile curve until last observation; d area under curve extrapolated to infinity | ||||
Shakeel et al. Journal of Nanobiotechnology 2008 6:8 doi:10.1186/1477-3155-6-8 |
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