Development of a tumor cell type-selective and cancer gene-specific nanocomplex for ALCL cells. A, A nano-sized carrier core structure was initially formed via aggregation of polyethyleneimine (PEI) and crosslinking with sodium citrate (PEI-citrate nanocore). The synthetic RNA-based CD30 aptamers and ALK siRNA were then incorporated onto the PEI-citrate nanocore to form the nanocomplex. B, When the functional RNA nanocomplex is added to cultures, the aptamer component will selectively target CD30-positive ALCL cells. Aptamer-mediated cell binding will facilitate intracellular delivery of the nanocomplex. The siRNA component will subsequently silence the cellular ALK gene, resulting in the growth arrest of ALCL cells.
Zhao et al. Journal of Nanobiotechnology 2011 9:2 doi:10.1186/1477-3155-9-2